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Semaglutide is a Glucagon-like peptide-1 (GLP-1) produced by the gut. It increases insulin production, a hormone that lowers the blood sugar level while inhibiting glucagon secretion, which is a hormone that raises blood sugar, and reduces appetite and energy intake while delaying gastric emptying. It was first developed in 2012 as a longer-acting option for Liraglutide. In 2017 this drug was approved as an anti-diabetic medication used to treat type 2 diabetes and obesity. In June 2021, it got approved for chronic weight management in obese individuals with a (BMI) ≥ 30 kg/m2) or overweight (initial BMI ≥ 27 kg/m2) with at least one weight-related comorbidity. L-Carnitine is an amino acid that benefits energy levels by transporting fatty acids into the mitochondria, where they can be burned up and used as fuel. For this reason, many take carnitine as a weight-loss supplement to help accelerate fat burning. L-Carnitine is an amino acid that benefits energy levels by transporting fatty acids into the mitochondria, where they can be burned up and used as fuel. For this reason, many take carnitine as a weight-loss supplement to help accelerate fat burning.
To reduce adverse side effects, we recommend starting with the dose escalation chart below:
Week 1= 10 units, Week 2 = 20 units, Week 3 = 30, Week 4 = 40 units
Do not exceed 40 units. 20units or 30 units may be the right dose per patient, it usually takes 6-7 months to go up to 40 units.
Weeks 1-4 inject 25 units (2.5mg) SQ weekly. Weeks 5+ inject 50 units (5mg) SQ weekly. Anything over 5mg weekly, you would need more than one vial for a month’s supply. The max dose is 15mg weekly which is more for DM2.
Sample Dose Escalation Schedule | |||
Weeks | Weekly Dose | Number of units | Dose Escalation |
1 – 4 | 2.5mg | 25 | |
5 – 8 | 5mg | 50 | |
9 – 12 | 7.5mg | 75 | |
13 -16 | 10mg | 100 | |
17-20 | 12.5mg | 125 | |
21-24 | 15mg | 150 |